Pubblicazioni

'Back to a false normality': new intriguing mechanisms of resistance to PARP inhibitors.

Incorvaia L, Passiglia F, Rizzo S, Galvano A, Listi' A, Barraco N, Maragliano R, Calo' V, Natoli C, Ciaccio M, Bazan V, Russo A.

Oncotarget. 2016-12-31. 2016 Dec 31. doi: 10.18632/oncotarget.14409.    LEGGI...

Long-term outcome of breast cancer patients with pathologic N3a lymph node stage.

Grassadonia A, Vici P, Gamucci T, Moscetti L, Pizzuti L, Mentuccia L, Iezzi L, Scognamiglio MT, Zilli M, Giampietro J, Graziano V, Natoli C, Tinari N.

Breast. 2016-12-18. 2017 Jan 5;32:79-86. doi: 10.1016/j.breast.2016.12.018.    LEGGI...

Neoadjuvant Sequential Docetaxel Followed by High-Dose Epirubicin in Combination With Cyclophosphamide Administered Concurrently With Trastuzumab. The DECT Trial.

Pizzuti L, Barba M, Giannarelli D, Sergi D, Botti C, Marchetti P, Anza' M, Maugeri-Sacca' M, Natoli C, Di Filippo S, Catenaro T, Tomao F, Amodio A, Carpano S, Perracchio L, Mottolese M, Di Lauro L, Sanguineti G, Di Benedetto A, Giordano A, Vici P.

J Cell Physiol. 2016-11-15. 2016 Nov;231(11):2541-7. doi: 10.1002/jcp.25432.    LEGGI...

A Real-World Multicentre Retrospective Study of Paclitaxel-Bevacizumab and Maintenance Therapy as First-Line for HER2-Negative Metastatic Breast Cancer

Gamucci T, Mentuccia L, Natoli C, Sperduti I, Cassano A, Michelotti A, Di Lauro L, Sergi D, Fabi A, Sarobba MG, Marchetti P, Barba M, Magnolfi E, Maugeri-Sacca' M, Rossi E, Sini V, Grassadonia A, Pellegrini D, Astone A, Nistico' C, Angelini F, Vaccaro A, Pellegrino A, De Angelis C, Palleschi M, Moscetti L, Bertolini I, Buglioni S, Giordano A, Pizzuti L, Vici P.

J Cell Physiol. 2016-11-11. 2016 Nov 11. doi: 10.1002/jcp.25685.    LEGGI...

The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?

Bronte G, Incorvaia L, Rizzo S, Passiglia F, Galvano A, Rizzo F, Rolfo C, Fanale D, Listi' A, Natoli C, Bazan V, Russo A.

Crit Rev OncolHematol. 2016-08-11. 2016 Nov;107:20-32. doi: 10.1016/j.critrevonc.2016.08.011.    LEGGI...

Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy.

Vici P, Ercolani C, Di Benedetto A, Pizzuti L, Di Lauro L, Sperati F, Terrenato I, Gamucci T, Natoli C, Di Filippo F, Botti C, Barba M, Mottolese M, De Maria R, Maugeri-Sacca' M

J ExpClinCancer Res. 2016-04-02. 35(1):62. doi: 10.1186/s13046-016-0338-7.    LEGGI...

The comparison of outcomes from tyrosine kinase inhibitor monotherapy in second- or third-line for advanced non-small-cell lung cancer patients with wild-type or unknown EGFR status

Bronte G, Franchina T, Alu' M, Sortino G, Celesia C, Passiglia F, Savio G, Laudani A, Russo A, Picone A, Rizzo S, De Tursi M, Gambale E, Bazan V, Natoli C, Blasi L, Adamo V, Russo A

Oncotarget. 2016-03-16. doi: 10.18632/oncotarget.8130. [Epubahead of print].    LEGGI...

PD-L1 expression as predictive biomarker in patients with NSCLC: a pooledanalysis

Passiglia F, Bronte G, Bazan V, Natoli C, Rizzo S, Galvano A, Listi' A, Cicero G, Rolfo C, Santini D, Russo A.

Oncotarget. 2016-02-22. doi: 10.18632/oncotarget.7582.    LEGGI...

"Triple positive" early breast cancer: an observational multicenter retrospective analysis of outcome

Vici P, Pizzuti L, Sperduti I, Frassoldati A, Natoli C, Gamucci T, Tomao S, Michelotti A, Moscetti L, Gori S, Baldini E, Giotta F, Cassano A, Santini D, Giannarelli D, Di Lauro L, Corsi DC, Marchetti P, Sini V, Sergi D, Barba M, Maugeri-Sacca' M, Russillo M, Mentuccia L, D'Onofrio L, Iezzi L, Scinto AF, Da Ros L, Bartolini I, Basile ML, Rossi V, De Maria R, Montemurro F.

Oncotarget. 2016-02-18. doi: 10.18632/oncotarget.7480.    LEGGI...

Beyond evidence-based data: scientific rationale and tumorbehavior to drive sequential and personalized therapeutic strategies for the treatment of metastatic renal cell carcinoma

Incorvaia L, Bronte G, Bazan V, Badalamenti G, Rizzo S, Pantuso G, Natoli C, Russo A.

Oncotarget. 2016-02-08. doi: 10.18632/oncotarget.7267.    LEGGI...

Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis

Vici P, Di Benedetto A, Ercolani C, Pizzuti L, Di Lauro L, Sergi D, Sperati F, Terrenato I, Dattilo R, Botti C, Fabi A, Ramieri MT, Mentuccia L, Marinelli C, Iezzi L, Gamucci T, Natoli C, Vitale I, Barba M, Mottolese M, De Maria R, Maugeri-Sacca' M.

Oncotarget. 2015-12-15. 6(40):42773-80. doi: 10.18632/oncotarget.6001.    LEGGI...

Is the skin a sanctuary for breast cancer cells during treatment with anti-HER2 antibodies?

Graziano V, Scognamiglio MT, Zilli M, Giampietro J, Vici P, Natoli C, Grassadonia A.

Cancer Biol Ther. 2015-11-09. [Epubahead of print].    LEGGI...

What links BRAF to the heartfunction? new insights from the cardiotoxicity of BRAF inhibitors in cancer treatment.

Bronte E, Bronte G, Novo G, Bronte F, Bavetta MG, Lo Re G, Brancatelli G, Bazan V, Natoli C, Novo S, Russo A.

Oncotarget. 2015-11-03. 6(34):35589-601. doi: 10.18632/oncotarget.5853.    LEGGI...

Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis.

Vici P, Di Benedetto A, Ercolani C, Pizzuti L, Di Lauro L, Sergi D, Sperati F, Terrenato I, Dattilo R, Botti C, Fabi A, Ramieri MT, Mentuccia L, Marinelli C, Iezzi L, Gamucci T, Natoli C, Vitale I, Barba M, Mottolese M, De Maria R, Maugeri-Sacca' M.

Oncotarget. 2015-10-17. doi: 10.18632/oncotarget.6001. [Epubahead of print].    LEGGI...

Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.

Vincenzi B, Cremolini C, Sartore-Bianchi A, Russo A, Mannavola F, Perrone G, Pantano F, Loupakis F, Rossini D, Ongaro E, Bonazzina E, Dell'Aquila E, Imperatori M, Zoccoli A, Bronte G, De Maglio G, Fontanini G, Natoli C, Falcone A, Santini D, Onetti-Muda A, Siena S, Tonini G, Aprile G.

Oncotarget. 2015-10-13. 6(31):31604-12. doi: 10.18632/oncotarget.5231.    LEGGI...

Effect of targeted agents on the endocrine response of breast cancer in the neoadjuvant setting: a systematic review.

Grassadonia A, Caporale M, Tinari N, Zilli M, DeTursi M, Gamucci T, Vici P, Natoli C.

J Cancer. 2015-05-12. 6(6):575-82. doi: 10.7150/jca.11566. eCollection 2015.    LEGGI...

Identification of subgroups of early breast cancer patients at high risk of nonadherence to adjuvant hormone therapy: results of an Italian survey.

Tinari N, Fanizza C, Romero M, Gambale E, Moscetti L, Vaccaro A, Seminara P, Longo F, Gori S, Vici P, Gamucci T, Mauri M, Laudadio L, Nuzzo A, Fabbri MA, Fattoruso SI, Mazzilli L, Grassadonia A, Cianchetti E, Natoli C.

Clin Breast Cancer. 2015-04-15. e131-7. doi: 10.1016/j.clbc.2014.10.005. Epub 2014 Oct 22.    LEGGI...

Endothelin A receptor/Beta-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy.

Rosano' L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Caprara V, Semprucci E, Ferrandina G, Natali PG, Bagnato A

Cancer Res. 2014-12-15. 74(24):7453-64. doi: 10.1158/0008-5472.CAN-13-3133. Epub 2014 Nov 6.    LEGGI...

Chemotherapy-induced nausea and vomiting in Italian cancer centers: results of CINVDAY, a prospective, multicenter study.

Chemotherapy-induced nausea and vomiting in Italian cancer centers: results of CINVDAY, a prospective, multicenter study.

Tumori. 2014-11-15. 100(6):e309-13. doi: 10.1700/1778.19310.    LEGGI...

Membranous Nectin-4 expressionis a risk factor for distant relapse of T1-T2, N0 luminal-A early breast cancer.

Membranous Nectin-4 expressionis a risk factor for distant relapse of T1-T2, N0 luminal-A early breast cancer.

Oncogenesis. 2014-09-01. 3:e118. doi: 10.1038/oncsis.2014.32.    LEGGI...

High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process

Grassilli S, Brugnoli F, Lattanzio R, Rossi C, Perracchio L, Mottolese M, Marchisio M, Palomba M, Nika E, Natali PG, Piantelli M, Capitani S, Bertagnolo V

Oncotarget. 2014-06-30. 5(12):4320-36..    LEGGI...

Breast cancer "tailored follow-up" in Italian oncology units: a web-based survey.

Natoli C, Brocco D, Sperduti I, Nuzzo A, Tinari N, De Tursi M, Grassadonia A, Mazzilli L, Iacobelli S, Gamucci T, Vici P; 'FOLLOW-UP' Study Group

PLoSOne. 2014-04-08. 8;9(4):e94063. doi: 10.1371/journal.pone.0094063. eCollection 2014.    LEGGI...

EV20, a Novel Anti-ErbB-3 Humanized Antibody, Promotes ErbB-3 Down-Regulation and Inhibits Tumor Growth In Vivo

Sala G, Rapposelli IG, Ghasemi R, Piccolo E, Traini S, Capone E, Rossi C, Pelliccia A, Di Risio A, D'Egidio M, Tinari N, Muraro R, Iacobelli S; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO)

Transl Oncol. 2013-12-01. 6(6):676-84. eCollection 2013 Dec 1.    LEGGI...

Overexpression of activated phospholipase Cgamma1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy

Lattanzio R, Marchisio M, La Sorda R, Tinari N, Falasca M, Alberti S, Miscia S, Ercolani C, Di Benedetto A, Perracchio L, Melucci E, Iacobelli S, Mottolese M, Natali PG, Piantelli M; CINBO(Consorzio Interuniversitario Nazionale per Bio-Oncologia).

Int J Cancer. 2013-03-01. 132(5):1022-31. doi: 10.1002/ijc.27751. Epub 2012 Sep 1.    LEGGI...

Beta-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced Beta-cateninsignaling

Rosano' L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Spadaro F, Salvati E, Biroccio AM, Natali PG, Bagnato A.

Oncogene. 2012-12-03. doi: 10.1038/onc.2012.527. [Epubahead of print].    LEGGI...

LMNA knock-down affects differentiation and progression of human neuroblastoma cells

Maresca G, Natoli M, Nardella M, Arisi I, Trisciuoglio D, Desideri M, Brandi R, D’Aguanno S, Nicotra MR, D’Onofrio M, Urbani A, Natali PG, Del Bufalo D, Felsani A, D’Agnano I

PLoSOne. 2012-09-26. 7(9):e45513. doi: 10.1371/journal.pone.0045513. Epub 2012 Sep 26.    LEGGI...

Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells

Spinella F, Caprara V, Di Castro V, Rosano' L, Cianfrocca R, Natali PG, Bagnato A.

J Mol Med (Berl). 2012-09-11. [Epubahead of print].    LEGGI...

Overexpression of activated phospholipase Cgamma1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy

Lattanzio R, Marchisio M, La Sorda R, Tinari N, Falasca M, Alberti S, Miscia S, Ercolani C, Di Benedetto A, Perracchio L, Melucci E, Iacobelli S, Mottolese M, Natali PG, Piantelli M; on behalf of CINBO (Consorzio Interuniversitario Nazionale per la Bio-Oncologia).

Int J Cancer. 2012-07-31. doi: 10.1002/ijc.27751. [Epubahead of print].    LEGGI...

Melanoma molecular classes and prognosis in the postgenomic era

Tremante E, Ginebri A, Lo Monaco E, Frascione P, Di Filippo F, Terrenato I, Benevolo M, Mottolese M, Pescarmona E, Visca P, Natali PG, Giacomini P.

Lancet Oncol. 2012-05-13. 13(5):e205-11. doi: 10.1016/S1470-2045(12)70003-7.    LEGGI...

An ErbB-3 antibody, MP-RM-1, inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3/Ak tsignaling

Sala G, Traini S, D'Egidio M, Vianale G, Rossi C, Piccolo E, Lattanzio R, Piantelli M, Tinari N, Natali PG, Muraro R, Iacobelli S; Consorzio Interuniversitario Nazionale per la Bio-Oncologia

Oncogene. 2012-03-08. 31(10):1275-86. doi: 10.1038/onc.2011.322. Epub 2011 Aug 8.    LEGGI...

Cell-to-cell signaling influences the fate of prostate cancer stem cells and their potential to generate more aggressive tumors

Salvatori L, Caporuscio F, Verdina A, Starace G, Crispi S, Nicotra MR, Russo A, Calogero RA, Morgante E, Natali PG, Russo MA, Petrangeli E.

PLoSOne. 2012-02-06. 7(2):e31467. doi: 10.1371/journal.pone.0031467. Epub 2012 Feb 6.    LEGGI...

Meta-analysis of phase III trials of docetaxel alone or in combination with chemotherapy in metastaticb reastcancer

Belfiglio M, Fanizza C, Tinari N, Ficorella C, Iacobelli S, Natoli C; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO)

J Cancer Res Clin Oncol. 2011-11-18. 2012 Feb;138(2):221-9. doi: 10.1007/s00432-011-1091-0. Epub 2011 Nov 18.    LEGGI...

Fucans, but not fucomanno glucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed

Croci DO, Cumashi A, Ushakova NA, Preobrazhenskaya ME, Piccoli A, Totani L, Ustyuzhanina NE, Bilan MI, Usov AI, Grachev AA, Morozevich GE, Berman AE, Sanderson CJ, Kelly M, Di Gregorio P, Rossi C, Tinari N, Iacobelli S, Rabinovich GA, Nifantiev NE; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO),Italy

PLoSOne. 2011-02-28. 6(2):e17283. doi: 10.1371/journal.pone.0017283.    LEGGI...

Tyrosine kinase inhibitors

Natoli C, Perrucci B, Perrotti F, Falchi L, Iacobelli S; Consorzio Interuniversitario Nazionale per Bio-Oncologia (CINBO)

Curr Cancer Drug Targets. 2010-08-01. 10(5):462-83.    LEGGI...

Triplet schedule of weekly 5-fluorouracil and alternating irinotecan or oxaliplatin in advanced colorectal cancer: a dose-finding and phase II study

Morelli MF, Santomaggio A, Ricevuto E, Cannita K, De Galitiis F, Tudini M, Bruera G, Mancini M, Pelliccione M, Calista F, Guglielmi F, Martella F, Lanfiuti Baldi P, Porzio G, Russo A, Gebbia N, Iacobelli S, Marchetti P, Ficorella C.

Oncol Rep. 2010-06-01. 23(6):1635-40.    LEGGI...

Relations betweenstrain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice

Ahowesso C, Piccolo E, Li XM, Dulong S, Hossard V, La Sorda R, Filipski E, Tinari N, Delaunay F, Iacobelli S, Levi F.

Toxicol Lett. 2010-02-15. 192(3):395-401. Epub 2009 Nov 29.    LEGGI...

Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis

Iurisci I, Cumashi A, Sherman AA, Tsvetkov YE, Tinari N, Piccolo E, D'Egidio M, Adamo V, Natoli C, Rabinovich GA, Iacobelli S, Nifantiev NE; Consorzio Interuniversitario Nazionale Per la Bio-Oncologia

Anticancer Res. 2009-01-29. 29(1):403-10.    LEGGI...

High expression of 90K (Mac-2 BP) isassociated with poors urvival in node-negative breast cancer patients no treceiving adjuvant systemic therapies

Tinari N, Lattanzio R, Querzoli P, Natoli C, Grassadonia A, Alberti S, Hubalek M, Reimer D, Nenci I, Bruzzi P, Piantelli M, Iacobelli S; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO)

Tinari N, Lattanzio R, Querzoli P, Natoli C, Grassadonia A, Alberti S, Hubalek M, Reimer D, Nenci I, Bruzzi P, Piantelli M, Iacobelli S; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO). 2009-01-15. 124(2):333-8.    LEGGI...

Molecular mechanisms of endocrine resistance and their implication in the therapy of breast cancer

Zilli M, Grassadonia A, Tinari N, Di Giacobbe A, Gildetti S, Giampietro J, Natoli C, Iacobelli S; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO)

Biochim Biophys Acta. 2008-08-29. 1795(1):62-81. Epub 2008 Aug 29.    LEGGI...

Upstream stimulatory factor regulates constitutive expression and hormonal suppression of the 90K (Mac-2BP) protein

Grassadonia A, Tinari N, Fiorentino B, Nakazato M, Chung HK, Giuliani C, Napolitano G, Iacobelli S, Howcroft TK, Singer DS, Kohn LD; Consorzio Interuniversitario Nazionale per la Bioncologia.

Endocrinology. 2007-04-19. 148(7):3507-17. Epub 2007 Apr 19.    LEGGI...

A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and anti adhesive activities of nine different fucoidans from brown sea weeds

Cumashi A, Ushakova NA, Preobrazhenskaya ME, D'Incecco A, Piccoli A, Totani L, Tinari N, Morozevich GE, Berman AE, Bilan MI, Usov AI, Ustyuzhanina NE, Grachev AA, Sanderson CJ, Kelly M, Rabinovich GA, Iacobelli S, Nifantiev NE; Consorzio Interuniversitario Nazionale per la Bio-Oncologia, Italy

Glycobiology. 2007-02-12. 17(5):541-52. Epub 2007 Feb 12.    LEGGI...

Novel P53 mutations detected by FAMA in colorectal cancers

De Galitiis F, Cannita K, Tessitore A, Martella F, Di Rocco ZC, Russo A, Adamo V, Iacobelli S, Martinotti S, Marchetti P, Ficorella C, Ricevuto E; Consorzio Interuniversitario Nazionale Bio-Oncologia.

Ann Oncol.. 2006-06-01. 17 Suppl 7:vii78-83.    LEGGI...

Changes of topoisomerase II alpha expression in breast tumors after neoadjuvant chemotherapy predicts relapse-free survival

Tinari N, Lattanzio R, Natoli C, Cianchetti E, Angelucci D, Ricevuto E, Ficorella C, Marchetti P, Alberti S, Piantelli M, Iacobelli S

Clin Cancer Res. 2006-03-01. 12(5):1501-6.    LEGGI...